Jerry Lewis Telethon Performers ( 2010 )

The Jerry Lewis Telethon 2010 marks the 45th anniversary of the great endeavor,Jerry LewisJerry Lewis, 84, has been working to generate awareness for the dangerous children's disease that slowly kills muscle-controlling nerves and then causes death. The actor has been conducting the yearly Jerry Lewis Telethon, which has raised almost $2.4billion for research and treatment of muscular dystrophy and other neuromuscular diseases.

Jerry Lewis, the famous comedian who will be a part of the 2010 Jerry Lewis MDA Telethon tonight at 9 pm ET, told Inside Edition this week that if he came across Lindsay Lohan in the street, he would smack her as punishment for her prior drunken exploits, jail and rehab stints, and consistent negative press in the media.

Every year since 1966, the Jerry Lewis Telethon has taken place around Labor Day weekend. Well that time has come round again, and this year’s event – which raises money for the Muscular Dystrophy Association – is going to be kicking off very soon.

On Tonight: 'March of Time,' Telethon Start,Labor Day brings The 45th Annual Jerry Lewis MDA Telethon (WTIC, Channel 61, 10:45 p.m.). The MDA National Chairman and former comedy partner of Dean Martin, Jerry Lewis, 84, hoping to top last year's total of $60.4 million. Running all night and all day Monday, guests this year include Lynyrd Skynyrd, Enrique Iglesias, War, the Grascals and Barry Manilow.